Sexual Health
Once placed into a patient"s body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician.
This week, Swiss researchers presented positive data from an ongoing Phase II clinical study at the American Thoracic Society (ATS) International Conference that compared PARI Pharma"s inhaled IsoCrom, an isotonic 1% disodium cromoglycate (DSCG) solution, to inhaled corticosteroids (ICS) in 28 children with atopic asthma. Results showed decreases in mean asthma symptom scores without a change in lung function for both groups. These results were achieved with IsoCrom administered via a customized small droplet Investigational eFlow Nebulizer System designed to deliver drugs to the deep lungs. One of the benefits of DSCG is the long track record as an extremely safe drug.
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced that Interleukin 21 (IL-21) demonstrated an impressive overall response rate in the treatment of metastatic melanoma. In interim Phase 2 results from 24 patients, 29 percent showed a partial response, with an additional 33 percent of patients showing stable disease in this difficult to treat disease.
According to a new Mayo Clinic study, a history of child abuse significantly impacts the wide range of challenges facing depressed inpatients. Included are an increase in suicide attempts, prevalence of substance use disorder, and a higher incidence rate of personality disorder. Additionally, these victims also had an earlier onset of mental illness and an increase in psychiatric hospitalizations for psychiatric issues. The study was presented at the American Psychiatric Association 2009 Annual Meeting in San Francisco.
"Nature" journals are synonymous with the very best in research. Earlier this year, an article by University of Leicester bioengineer Professor Rodrigo Quian Quiroga not only appeared in Nature Reviews Neuroscience, but also featured on the magazine cover. In the article, Prof. Quian Quiroga and co-author Dr. Stefano Panzeri discuss new methodologies that are enabling scientists to better understand how our brain processes information.
Alkermes, Inc. (NASDAQ: ALKS) announced the initiation of two new clinical trials of ALKS 33, an oral opioid modulator for the potential treatment of addiction and other nervous system disorders. Study ALK33-004 is a phase 1 clinical trial designed to examine the ability of ALKS 33 to block the effects of an opioid following a single oral dose of ALKS 33 in healthy, non-dependent, opioid-experienced subjects. Study ALK33-003 is a phase 1 clinical trial designed to evaluate the pharmacokinetics, safety and tolerability of multiple doses of ALKS 33 in healthy volunteers.
In studying the preventive effects of vitamin D, researchers at the Moores Cancer Center at the University of California, San Diego, have proposed a new model of cancer development that hinges on a loss of cancer cells" ability to stick together. The model, dubbed DINOMIT, differs substantially from the current model of cancer development, which suggests genetic mutations as the earliest driving forces behind cancer.
The Tennessee House on Monday voted 76-22 to approve a resolution (S.J.R. 127) to amend the state constitution to allow the Legislature to impose stricter limits on abortion, the AP/Memphis Commercial Appeal reports. The resolution, which aims to void a 2000 Tennessee Supreme Court ruling, was passed by the state Senate in March, but it still has hurdles to overcome. In order to change the state constitution, the measure will have to be approved by a two-thirds majority of both houses in the next General Assembly, either in 2011 or 2012, before it could go to voters in 2014.The 2000 court decision declared that the state constitution provides stronger protections than the U.S. Constitution for abortion rights. The decision nullified a number restrictions the Tennessee Legislature previously had adopted, including requirements that clinics provide women with specific information about abortion procedures, a 48-hour waiting period and a requirement that all but first trimester abortions take place in hospitals.The measure would add a provision to the state constitution declaring that, "Nothing in this constitution secures or protects a right to abortion, or requires the funding of an abortion. The people retain the right through their elected state representatives and state senators to enact, amend or repeal statutes regarding abortion, including but not limited to circumstances of pregnancy resulting from rape or incest or when necessary to save the life of the mother." An amendment to the resolution failed on Monday that would have allowed abortions in "cases involving rape or incest or in cases where the procedure is medically necessary to save the life of the pregnant woman." Rep. Debra Maggart (R), sponsor of the resolution, said that it "just returns the constitution of the state of Tennessee to neutral on the subject of abortion."Rep. Henry Fincher (D) said, "Assuming there"s no change in the makeup of the General Assembly, there"s a good chance that it will pass then and go to the ballot." Rep. Jeanne Richardson (D) said, "I have a feeling that in this country if a majority of women tried to tell men what to do in their sex lives and what to do with their own bodies, it would fail utterly and miserably" (Johnson, AP/Memphis Commercial Appeal, 5/19).
Supporters of Planned Parenthood of Kansas and Mid-Missouri are urging Gov. Mark Parkinson (D) to veto a provision in a budget bill (H.B. 2373) that would eliminate the group"s funding, the AP/Wichita Eagle reports. The bill aims to balance Kansas" budget for the fiscal year that begins July 1. The original bill was approved by the Legislature and former Gov. Kathleen Sebelius, who resigned in April to become HHS secretary. It included $250,000 in state funding for Planned Parenthood for FY 2010. However, lawmakers later amended the budget with a new bill that includes a provision eliminating the funding after state revenue projections declined, the AP/Eagle reports.While antiabortion-rights advocates want Parkinson to retain the provision, about two dozen supporters of Planned Parenthood gathered on Tuesday to urge Parkinson to line-item veto the provision. They left petitions at the governor"s office with about 3,500 signatures, the AP/Eagle reports. Planned Parenthood attorney Pedro Irigonegarary said the loss of funding would negatively impact "a large number of innocent people." He added that the group "is about family values. They have taken those two words from us and now it"s time to take them back." According to the AP/Eagle, Planned Parenthood said the state funding is given to its Ellis and Sedgwick county clinics, which do not perform abortions. The group also noted that no state funds are used for abortion procedures performed at its clinics in Overland Park, a suburb of Kansas City.The governor"s office said that Parkinson intends to act on the bill sometime this week, although he will not announce what action he will take on any legislation in advance. Parkinson has said that he holds "very similar" views on abortion rights as Sebelius, who supports such rights. However, he has yet to act on any bills regarding abortion, the AP/Eagle reports. Mary Kay Culp, executive director of Kansans for Life, said that the group is asking members to contact legislators and the governor"s office in support of retaining the measure. The AP/Eagle reports that if Parkinson vetoes the measure, lawmakers could attempt to override it (Manning, AP/Wichita Eagle, 5/19).
"The Supreme Court keeps finding ways to deny women equal pay and benefits," a New York Times editorial states in response to the court"s 7-2 ruling on Monday that employers are not required to award women credit toward pension benefits for pregnancy leave taken before Congress passed the 1978 Pregnancy Discrimination Act. According to the Times, the ruling reflects reasoning similar to the court"s 2007 decision in which it denied former Goodyear employee Lilly Ledbetter"s "claim for equal pay because it thought she waited too long to file it." In Monday"s decision, the majority "reasoned mainly that the pregnancy leaves predated the 1978 law, and since the law was not retroactive, the discrepancy in benefits was the product of "past completed events that were entirely lawful at the time they occurred,"" the editorial states. It notes that the majority included "two generally reliable votes for equality, Justices John Paul Stevens and David Souter." The editorial continues, "This may sound logical, but it is not just." The editorial says that Justice Ruth Bader Ginsburg, in writing the dissent, "quite correctly" recognized a company"s "ongoing denial of equal benefits not as past discriminatory behavior that started and ended decades ago, but as a current violation of the act." In a similar way, "Goodyear discriminated against Lilly Ledbetter by maintaining her unequal pay for years, not merely the first time the company underpaid her." The Times calls on Congress to "write corrective legislation" on pregnancy leave (New York Times, 5/21).
The Washington Times recently published an opinion piece and an editorial discussing President Obama"s nomination of Indiana University law professor Dawn Johnsen to head the Office of Legal Counsel in the Justice Department. Summaries appear below. ~ Mickey Edwards/William Sessions, Washington Times: The Senate should "act expeditiously to approve" Johnsen"s nomination because "her views on the limits of presidential power are precisely what the Constitution envisions and conservatives have long championed," Edwards, vice president of the Aspen Institute and author of "Reclaiming Conservatism," and Sessions, a partner at the law firm Holland & Knight, write in a Times opinion piece. According to the authors, Johnsen "made her views clear" on the limits of presidential power when she joined a bipartisan group of lawyers that declared that the Office of Legal Counsel should promote "presidential adherence to the rule of law." Edwards and Sessions write that Johnsen is being criticized for "being blunt, unserious and critical of presidential policies." However, these attacks are unwarranted, they write, noting that in the legal profession, "a little blunt talk to a client -- in this case, the president of the United States -- might be required." Edwards and Sessions continue, "What is needed in the Office of Legal Counsel is a person with the constitutional understanding to know that even presidents with whose politics she agrees must obey both the Constitution and federal statutes and who has the gumption to say so, even if the advice won"t be well received" (Edwards/Sessions, Washington Times, 5/21).~ Washington Times: The editorial states that Johnsen "is so radical" that 31 Republican Indiana state senators on Monday sent a letter to Sens. Evan Bayh (D-Ind.) and Dick Lugar (R-Ind.) asking them to oppose her confirmation. The Republican senators called Johnsen"s views supporting abortion rights "extremely radical" and said she often uses "harsh, sensationalizing rhetoric" in her writings on Supreme Court cases, the editorial states. According to the editorial, Johnsen"s "political advocacy shows a profound disregard for the courts" proper role" because she considers the courts "as making up just another political, policymaking branch of government, not as bodies restrained by the Constitution or existing laws." The editorial continues that Johnsen is "guilty" of "asking judges to impose their own policy preferences" in favor of abortion rights "against the dictates of existing constitutional law." The editorial concludes, "Someone with such contemptuous views of the Constitution should not be the Obama administration"s chief constitutional interpreter" (Washington Times, 5/21).
Millions of children will continue to die of preventable causes unless health and development ministers get their priorities straight next week in Geneva, says leading aid agency World Vision.
HIV in Europe is transmitted primarily in vacation destinations, according to a study published recently in the journal Retrovirology, the PA/Google.com reports. For the study, researchers led by Dimitrios Paraskevis of the University of Athens analyzed samples of HIV-1 subtype B virus, the most prevalent form of HIV in Europe, from 16 European countries and Israel (PA/Google.com, 5/20). The researchers created a family tree of the virus and examined its genetic characteristics to determine how it has evolved.The study found that tourists are more likely to contract HIV in Greece, Portugal, Serbia and Spain, which are popular vacation destinations. Meanwhile, HIV-positive people in Austria, Belgium, Denmark and Luxembourg are more likely to have contracted the virus outside of these countries. The study also found that HIV-positive people in Israel, Norway, the Netherlands, Sweden, Switzerland and the United Kingdom contract the virus both within these countries and in other countries. In addition, the study found that in Poland the virus spread mainly among residents through injection drug use. "Viruses move around with travelers -- thus health programs within countries should not only target the national populations, prevention efforts must also be aimed at migrants, travelers and tourists -- who are both major s and targets of HIV," Paraskevis said (BBC News, 5/20). Lisa Power, head of policy at the Terrence Higgins Trust, said that the findings are not a "surprise," adding, "We"ve known for some time with high levels of mobility in the world these days that it"s very easy for viruses to move around. What it tells us is that you can"t limit HIV prevention and support just to permanent residents" (PA/Google.com, 5/20).
Regulatory processes differ across continents,
Molecular superfamily causes melanoma spread A superfamily of molecules holds the secret to the development and spread of melanoma - the deadliest form of skin cancer, revealed a study published in the British Journal of Cancer*.
A class of drugs already approved as cancer treatments might also help to beat alcohol addiction. That"s the conclusion of a discovery in flies of a gene, dubbed happyhour, that has an important and previously unknown role in controlling the insects" response to alcohol.
Women who develop gestational diabetes (GD) during pregnancy have a seven-and-a-half times increased risk of developing type 2 diabetes post-birth, which lasts throughout their lifetime. However, there is no agreed policy on the long-term follow up of these women and many do not return for the currently recommended 6-week post-birth diabetes check. An Article in this week"s diabetes special issue of The Lancet says that the strength of the association suggests that both disorders have an overlapping cause-and this should act as an incentive for women to attend the recommended post-birth check. This attendance could be an opportunity to provide advice on diet and exercise, and treatments to delay or prevent onset of diabetes-as well as alerting these women to symptoms of future diabetes, and to alert general practitioners responsible for their long-term care.
Three quarters (75%) of women with BV (Bacterial Vaginosis) admit the condition has prevented them from getting intimate with their partner, according to a new survey by Balance ActivTM Vaginal Gel.1 Sufferers reveal BV affects their personal relationships more than any other aspect of their lives, with one in ten sufferers resorting to ending relationships as a result of the embarrassing symptoms.1
Genzyme Corp. (NASDAQ: GENZ) and Isis Pharmaceuticals Inc. (NASDAQ: ISIS) today announced that the phase 3 study of mipomersen in patients with homozygous familial hypercholesterolemia (hoFH) met its primary endpoint, with a 25 percent reduction in LDL cholesterol after 26 weeks of treatment, vs. 3 percent for placebo (pAbout Familial Hypercholesterolemia (FH)
Geneticists at Signature Genomic Laboratories recently demonstrated that microarray-based genetic testing can identify chromosome abnormalities that cause genetic disorders associated with susceptibility to cancer prior to the onset of symptoms.
New research from the US suggests that people who drink from bottles made of polycarbonate plastic, such as that used to make hard-plastic
BioCryst Pharmaceuticals (Nasdaq: BCRX) announced long-term data from a Phase 2 study of forodesine, the Company"s lead oncology compound, in patients with cutaneous T-cell lymphoma (CTCL). The data will be presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) being held in Orlando, Florida from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.
Researchers at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, are strongly advocating a national discussion about the need to vaccinate both young men and women against HPV 16 to prevent head & neck cancers. The call comes amid growing evidence that certain cancers of the head and neck are strongly linked to HPV 16, a specific strain of the human papillomavirus (HPV) that is one of the most common sexually transmitted diseases in the United States. It is estimated that approximately 70% of Americans, both men and women, will be infected with HPV at some point in their lives.
The FDA (Food and Drug Administration) has approved Samsca (tolvaptan), in tablet form, for the treatment of hyponatremia. Hyponatremia is when levels of sodium in the blood are abnormally low - it is associated with dehydration.
Drinking on college campuses in the United States is a pervasive problem, leading to numerous problems. One study estimated that more than 500,000 college students suffered alcohol-related injuries in 2001. This study examined the "dose-response" effect of quantities and frequencies, finding that heavy drinkers with a sensation-seeking disposition had the greatest risk of alcohol-related injuries.
Senate Finance Committee Chair Max Baucus (D-Mont.) on Thursday said that Congress" health care overhaul plan would cover 94% to 96% of the population but not undocumented immigrants, the AP/Las Vegas Sun reports (Alonso-Zaldivar, AP/Las Vegas Sun, 5/21). In remarks at a briefing sponsored by the Kaiser Family Foundation, Families USA and the National Federation of Independent Business, Baucus said, "There are always going to be some people ... you just can"t find" to enroll, adding that "we"re going to try to get as close as we can (to 100% coverage) and we"re working hard to accomplish that." He added, "[W]e"re not going to cover undocumented workers. That"s too politically explosive" (Reichard, CQ HealthBeat, 5/21). According to an analysis by the Center for Immigration Studies and the U.S. Census Bureau, undocumented immigrants make up between 15% and 22% of the estimated 47 million U.S. residents without health coverage. Baucus said, "I don"t have a good answer yet to undocumented workers, illegal aliens," adding, "There will still be charity care " (Landers, Dallas Morning News, 5/22). Baucus said that the bill his committee is working on and that he expects to mark up in mid-June will include "incentives" and possibly requirements for employers to pay for employee health insurance. Baucus mentioned the possibility of including an individual mandate and establishing a health insurance exchange (AP/Las Vegas Sun, 5/21). Baucus also noted that the plan most likely will include a public health insurance option in some form (Tumulty, "Swampland," Time Magazine, 5/21). "Everything"s on the table," Baucus said, warning that "because this is so big, so complex, there are going to be a lot of trade-offs. ... This is just so large" (CQ HealthBeat, 5/21). He said that he is very optimistic about the prospects of bipartisan support for the legislation, placing the odds at between 75% and 80% ("Swampland," Time Magazine, 5/21).
President Obama on Wednesday ordered federal agencies to rescind regulations enacted by former President George W. Bush"s administration that protect manufacturers of such products as medical devices from product-liability lawsuits in state court, the Wall Street Journal reports. The decision could affect a wide range of manufacturers and products because the Bush administration "aggressively" encouraged federal agencies to make rules that pre-empt and override state laws, which often meant protecting manufacturers of medical equipment from lawsuits, according to the Journal. Obama in a two-page memo wrote that federal agencies and departments could claim state law is pre-empted by federal law only when there is a well-defined legal basis. The memo stated that state laws are important because they supplement federal regulations. "State and local governments have frequently protected health, safety and environment more aggressively than has the national government," Obama wrote (Mundy/Kendall, Wall Street Journal, 5/21). Obama ordered agencies to review regulations from the past decade and look for possible occasions in which the government improperly declared federal pre-emption (Yost, AP/Kansas City Star, 5/20). According to the Journal, business groups oppose the decision (Wall Street Journal, 5/21).
A discovery made by researchers at McGill University and the affiliated Lady Davis Research Institute for Medical Research at Montreal"s Jewish General Hospital offers new hope for the early diagnosis and treatment of Alzheimer"s disease.
Colorectal cancer is thought to result from a combination of environmental factors: diet, lifestyle, chronic inflammation and accumulation of specific genetic alterations. The pathogenesis and development of colorectal cancer involves multi-genes and multi-steps. TSPAN1 (GenBank Accession No. AF065388) is a new member of TM4SF located at chromosome 1 p34.1. It encodes a 241 amino acid protein. TSPAN1 was reported as a tumor-related gene recently.
Although creatinine clearance (Ccr) has been measured clinically by a simple method as a preoperative renal function test, Ccr is not strictly equal to glomerular filtration rate (GFR). Recently, an equation for estimated GFR (eGFR) for Japanese individuals has been postulated, and eGFR has been accepted as equal to measured GFR in chronic kidney disease. However, there have been no previous studies regarding the reliability of eGFR as a preoperative renal function test.
Almirall announces today that the file for a regulatory submission for Sativex® for the treatment of spasticity due to multiple sclerosis has been submitted in UK and Spain under the European decentralised procedure. The UK regulatory authority, the Medicines and Healthcare products Regulatory Agency (MHRA), is acting as Reference Member State and has validated the application.
Arthritic knee joints may be repaired either partially or totally - known as partial knee replacement and total knee replacement. A partial knee replacement is also called unicompartmental or "UNI". If the bone disease is restricted to the inner side of the knee (the "medial" side), the surgeon will simply reshape those damaged surfaces. The repaired surfaces on that one side of the knee are then partially covered with a combination of metal and plastic bearings. For this reason, a UNI knee replacement is considered less invasive and can provide much shorter recovery times from the operation.
Two leading HIV charities have today launched a guide for people living with HIV in England and Wales explaining criminal prosecutions for HIV transmission.
Yesterday, a jury in the United States District Court for the District of Columbia found that the Federal Bureau of Investigation (FBI) discriminated against Jeff Kapche when it refused to hire him as a Special Agent because of his diabetes.
People with diabetes who were prescribed the cholesterol-lowering drug fenofibrate reduced their risk of minor amputations by 36 per cent, according to new research.
As the nation debates health reform options, the Center for Health Care Strategies (CHCS) is launching Transforming Care for Dual Eligibles , a state initiative to test innovative care models for people who are dually eligible for Medicare and Medicaid ("dual eligibles"). Colorado, Maryland, Massachusetts, Michigan, Pennsylvania, Texas, and Vermont will implement strategies to improve care and control costs for dual eligibles, a high-need population with health care costs nearly five times those of other Medicare beneficiaries. The program is made possible through support from The Commonwealth Fund.
Researchers at the University of Toronto and the University Health Network"s Centre for Innovation in Complex Care (CICC) have found that a wide array of health-related activity occurs in the 3 dimensional virtual world of Second Life. Second Life is free for users with basic accounts, and reported over 16 million registered users worldwide in 2008. The web-based platform, which is often associated with pornography and "cheating" spouses, is also used to educate people about illness, train physicians, nurses and medical students with virtual simulations, enable disease-specific support and discussion groups, fundraise real-life dollars for medical research, and to conduct research.
UroToday.com - In the only survey of BPS/IC conducted in Japan, done in urology clinics, the prevalence was estimated at 4.5/100,000 women.[Ito et al. 2000] Studies in Finland, Austria, and Taiwan using O"Leary-Sant questionnaires to identify persons with symptoms of BPS/IC have arrived at figures around 300/100,000 women.[Yu 2006;Leppilahti . 2005;Temml et al. 2007]
An international research collaboration coordinated by UCD researchers and involving scientists at 21 institutes including the genome sequencing centres in the Wellcome Trust Sanger Institute, UK and the Broad Institute at MIT and Harvard, USA have defined six new genome sequences in the Candida fungus family and identified genetic differences in species that cause disease.
Health Canada considers permitting vitamin and mineral (iron, calcium etc.) additives in high-calorie food products of all sorts, such as potato chips, energy bars, fruit flavored drinks. However dieticians and other health professionals caution that those products continue to be fortified junk food and that the little added nutritional value will boost consumption and enhance problems of obesity and diabetes.
National guidelines are needed for timely disclosure of medical errors and informing patients, write Toronto-based researchers in a review http://www.cmaj.ca/press/pg1125.pdf in CMAJ (http://www.cmaj.ca).
Statement of Charles D. Connor, American Lung Association President and CEO:
Children of parents who refuse vaccines are 23 times more likely to get whooping cough compared to fully immunized children, according to a new study led by a vaccine research team at Kaiser Permanente Colorado"s Institute for Health Research.
A multidisciplinary team of technology strategists and scientists from Cambridge Consultants has provided advice to Cambridge Enterprise Ltd., regarding potential applications for microdroplet technology in a high-growth sector of the drug discovery market, currently valued at US$140m.
The Government today responded to the independent inquiry into contaminated blood supplies in the 1970s and 1980s.
Medimix International, a leader in global healthcare marketing research for life sciences industry, announced that it will be exhibiting at the 45th AGM of the American Society of Clinical Oncology, which will take place in Orlando, Florida from May 29-June 2, 2009. The annual ASCO meeting is considered to be the premier educational and scientific event in the oncology community, a forum for cutting-edge scientific and educational developments in oncology with a focus on personalizing cancer care.
The World Health Organization (WHO) have refuted the suggestion made by Australian virologist Adrian Gibbs that the new A/H1N1 influenza
Researchers attending the annual meeting of the International Society for Pharmacoeconomics & Outcomes Research (ISPOR), heard today that prescribing Aricept® (donepezil hydrochloride) as soon as patients are diagnosed with either mild or moderate Alzheimer"s disease saves the NHS money. The findings contradict the recommendation by NICE that these medicines are not cost effective in the early stages of the disease, a decision that has been the subject of much recent debate.
The World Health Organization (WHO) and the International Atomic Energy Agency (IAEA) today announced the launch of a Joint Programme on Cancer Control, aimed at strengthening and accelerating efforts to fight cancer in the developing world.
The National Association of Pediatric Nurse Practitioners (NAPNAP) praises Representative Allyson Schwartz and nearly 100 cosponsors of The Preserving Patient Access to Primary Care Act for their leadership in health care reform. This legislation, which will increase the number of primary care providers and improve patient access to primary care services, is a critical step if we truly are to reform our health care delivery system. Our nation needs leaders like Representative Schwartz to affect real and lasting change in our health care system.
Viruses are molecular marauders, plundering cells for the res they
A proposal by a team of UC Davis scientists to develop the world"s first electron microscope capable of filming live biological processes has been awarded a $2 million grant from the National Institutes of Health.
TeleHealth Services, the nation"s leading provider of healthcare grade televisions and on-demand patient and staff interactive education solutions, has announced the implementation of its TIGR on-demand video education and entertainment system into Timpanogos Regional Hospital in Orem, Utah.
Driven by rising health care costs at home, nearly 1 million Californians cross the border each year to seek medical care in Mexico, according a new paper by UCLA researchers and colleagues published in the journal Medical Care.
A panel of senior advocates and health policy experts gathered on Capitol Hill
The potential of using stem cells to treat Alzheimer"s disease and other illnesses will be investigated by Victorian and Californian researchers under a US$22 million (US$28.7 million) collaboration, Innovation Minister Gavin Jennings said recently.
An Ohio State University researcher is shifting his development of an MRI-compatible treadmill to his start-up company and plans to have a device ready for clinical testing in three months. The treadmill could allow physicians to measure a patient"s heart during peak stress more accurately than the echocardiograph and nuclear imaging processes now widely used.
Eli Lilly and Company (NYSE: LLY) announced it will begin enrolling
The Excellence in Oncology Awards (EinO) 2009 are now open for entry. The Awards, now in their fourth year, recognise and reward best practice in oncology management, education and patient care throughout the UK. Winners will be announced at a prestigious dinner on 6 October 2009 during the National Cancer Research Institute (NCRI) Cancer Conference.
The AMA says the most alarming element of last night"s budget is the total absence of health support measures for the unemployed.
Small businesses increasingly are eliminating their employee health coverage plans because of rising health care premiums and declining revenue attributed to the current economic recession, the Wall Street Journal reports. About 10% of small companies are considering ending their employee health coverage plans over the next year, compared with 3% of small businesses in 2005, according to a recent survey by the National Small Business Association. In 2008, 38% of small companies offered health coverage, compared with 41% in 2007 and 61% in 1993, according to NSBA. According to a Hewitt Associates survey, 19% of all U.S. businesses plan to halt providing health care benefits to their employees in the next three to five years.A rise in health care coverage premiums has contributed to employers eliminating plans, according to the Journal. Premiums for single policies increased by 74% for small businesses from 2001 to 2008, according to the Kaiser Family Foundation. According to Scott Krienke, senior vice president of product lines for Assurant Health, health insurance premiums for small businesses increase by 8% to 16% annually on average, with smaller firms often having the highest increases. According to the Journal, many employers are choosing to eliminate health coverage instead of eliminating jobs or closing down their business. Some businesses have chosen instead to shift more health care costs to workers, change health insurers, switch prescription drug plans to encourage employees to purchase more generic drugs or offer employees wellness plans that encourage healthy habits as a strategy to reduce health care costs, the Journal reports (Mattioli, Wall Street Journal, 5/26).
Rep. Frank Wolf (R-Va.) on Friday in a letter to President Obama said that the U.S. could lose its triple-A bond rating if Congress does not act quickly to overhaul U.S. entitlement programs, including Medicare and Medicaid, and reduce federal debt, the AP/Detroit News reports.Several lawmakers in Congress over the past two years have introduced bills to create a bipartisan task force to address the growing costs and potential insolvency of entitlement programs, such as Medicare and Medicaid. Wolf is a co-author of one such bill (HR 1557). A federal report issued earlier this month found that the trust fund Medicare uses to pay for beneficiaries" hospital care will be insolvent by 2017, two years earlier than previously predicted.According to the legislation, the task force would be responsible for developing a "grand bargain" package of recommendations to Congress on tax increases and benefits related to the entitlement programs. However, the task force has been opposed by House Speaker Nancy Pelosi (D-Calif.), several top congressional committee leaders and White House aides who said that other priorities, such as a health care system overhaul, need to be addressed first.Wolf said, "The fact that the leadership has been opposed to it has been a problem," adding, "There"s an economic tsunami off the coast and it"s ready to wipe us out." David Walker, president of the Peter G. Peterson Foundation, said that currently the potential for the task force is not good but that it should improve as the economy recovers and Congress can offer more attention to the plan (Raum, AP/Detroit News, 5/24). Opinion Pieces
Concerns regarding the H1N1 flu strain or the current global economic recession should not take attention away from the long-term fight against HIV/AIDS, Julio Mantaner, head of the International AIDS Society, said recently, VOA News reports. Mantaner said global health issues need to be "put ... into the proper perspective," adding, "No doubt that ... whatever new flu or any other epidemic that may show up the day after tomorrow ... is something that we need to respond to. But it cannot be at the expense of a proven, established killer" like HIV/AIDS. He said that although it is important to remain vigilant in detecting emerging epidemics and infectious diseases, "we"re (doing) ourselves a very serious disservice" when res are taken away from combating HIV/AIDS and given to "the next new potential epidemic."Mantaner said that although it is "clear that we failed to meet original targets" in the global fight against HIV/AIDS, there has been an increase in the number of HIV-positive people in developing countries receiving antiretroviral treatments from about 500,000 in 2003 to more than three million by the end of 2007. In addition, he said that antiretrovirals are "saving lives of people" and "preserving the social network, the family structure ... that is so severely compromised by HIV and AIDS." Despite this progress, Mantaner said that "[w]e need to recognize more [people] are being infected every day by a factor of nearly two than the number of people accessing antiretroviral therapy."Mantaner urged members of the World Health Assembly -- who recently met in Geneva -- to honor HIV/AIDS commitments, noting that the gains in fighting the pandemic cannot be reversed. He said that he is concerned the global recession, worries over the H1N1 flu and other "competing needs or hypothetical epidemics" could lead to donor nations "losing their interest" in fighting HIV/AIDS. Mantaner said that he is disappointed with President Obama"s recent $63 billion, six-year proposed global health initiative, adding that it falls short of his campaign promises. He said that IAS is asking leaders from the Group of Eight industrialized nations to "refocus their efforts" and "meet their commitments." He warned that if the commitments are not met, "[h]istory is going to judge us very harshly," adding, "We"ve been distracted by the epidemic of the day without recognizing that we have a killer within our midst that we can control" (DeCapua, VOA News, 5/21).
A study published in the June issue of Anesthesiology has shown that a drug metabolite of the opioid morphine may be a key factor in the paradoxical increased sensitivity to pain caused by chronic morphine use. For the first time, this metabolite (called morphine-6 glucuronide, or M6G) was shown to act independently of the pain receptors typically targeted during morphine administration.
Responding to Health Secretary Alan Johnson"s announcement of a review on the impact of the European Working Time Directive on doctors" training, Dr Andy Thornley, Chair of the BMA"s Junior Doctors Committee, said:
Coconino County Health Department (CCHD) officials announced today the first case of H1N1 (swine) flu in Coconino County. The Arizona Department of Health Services Lab confirmed that a 24 year-old male from the Navajo Nation has tested positive for the illness. The man went to the Tuba City Regional Health Care Corporation Emergency Department with flu-like symptoms and was tested. He is now recovering from the illness.
"The most lamentable and heart-breaking dimension of multilateralism" is the "absence of any serious focus on gender throughout" the United Nations system, Stephen Lewis, founder of AIDS-Free World, writes in a London Independent opinion piece. He adds, "I can cite chapter and verse, but let me start by telling you that whether it is poverty alleviation, or HIV and AIDS, or sexual violence and conflict, the whole panoply of discrimination visited on women around the world, particularly in developing countries, the U.N."s agencies and the Secretariat have been profoundly delinquent in their response."According to Lewis, the "struggle for gender equality has become the most important struggle on the planet; the continuing marginalization of 52% of the world"s population is simply unacceptable." He adds, "So we"re now engaged in an effort to create a new international agency for women, a fascinating undertaking that I hope will engage" governments. "Nothing approximates the possibility of finally having a vehicle that would give voice and res and support to the struggles of women around the world," Lewis writes, adding, "Everyone knows what"s happening in these areas about women"s vulnerability but there is never a consistent voice to bring it to the attention of the world community, to continue to hammer it home, to demand action from government." He concludes, "So the emergence and creation of a women"s agency I think would be a godsend internationally and would overcome the record of the United Nations on gender" (Lewis, Independent, 5/22).
Mountain climbers and adventurers who aspire to ascent Mount Everest have more information on immune function and the onset of acute mountain sickness (AMS), thanks to research presented today at the 56th Annual Meeting of the American College of Sports Medicine in Seattle. A team of medical students climbed to Everest Base Camp in order to find physical factors that would reveal information about illness severity in association with immune and hormonal responses to high-altitude exposure.
Affymax, Inc. (Nasdaq:AFFY) today announced data from a post hoc analysis of 120 patients in a Phase 2 clinical trial of Hematide™ in non-dialysis chronic kidney disease (CKD) patients. The data suggest that there is no major impact of baseline renal function as measured by Estimated Glomerular Filtration Rate (eGFR) on the monthly Hematide dose required to increase and maintain hemoglobin (Hgb) values within target range in non-dialysis CKD patients. The data were presented by Iain C. Macdougall, M.D. at the World Congress of Nephrology meeting being held in Milan, Italy.
A group of cancer patients, genetic researchers and professional pathologist organizations has filed a lawsuit against Myriad Genetics and the U.S. Patent Office over the patent of two genes associated with an increased risk of breast and ovarian cancers, the New York Times reports. According to the Times, the government more than 10 years ago granted Myriad the patent on the BRCA1 and BRCA2 genes, as well as the company"s genetic test that measures a patient"s risk for the cancers.The lawsuit was filed by the American Civil Liberties Union and is believed to be the first of its kind, the Times reports. The lawsuit challenges the decision to grant patents on genes to Myriad and companies like it. The plaintiffs say that patents on genes restrict medical and research efforts, while companies like Myriad have said that the patent system supports innovation by giving them a temporary monopoly after they make a discovery, thereby rewarding prior investment in research and development.Wendy Chung, the director of clinical genetics at Columbia University and a plaintiff in the case, said, "With a sole provider, there"s mediocrity." The plaintiffs say that BRCA testing would improve with market competition. Furthermore, some plaintiffs argue that certain natural materials cannot be patented. Jan Nowak, president of the Association for Molecular Pathology and a plaintiff in the case, said, "You can"t patent my DNA, any more than you can patent my right arm, or patent my blood."To date, two government panels, including the National Research Council, found no evidence that gene patents result in significant impediments to research or medical care (Schwartz, New York Times, 5/13).
Targeted Molecular Diagnostics (TMD), a Quintiles Central Laboratory, announced the availability of two new laboratory tests used to develop more effective cancer treatments.
Researchers at the University of Maryland School of Medicine have found that an approved drug for treating rheumatoid arthritis reduces severe illness and death in mice exposed to the Influenza A virus. Their findings suggest that tempering the response of the body"s immune system to influenza infection may alleviate some of the more severe symptoms and even reduce mortality from this virus.
Roche Diagnostics announced the launch of a new tuberculosis test for South Africa. Worldwide, South Africa is one of the countries with the highest prevalence of tuberculosis. The new kit detects different species of Mycobacterium from human sputum samples using the LightCycler® 2.0 Instrument.
Neuroscientists feel they are much closer to an accepted unified theory about how the brain processes speech and language, according to a scientist at Georgetown University Medical Center who first laid the concepts a decade ago and who has now published a review article confirming the theory.
A multicenter research team has announced encouraging results for an experimental therapy using elements of the body"s immune system to improve cure rates for children with neuroblastoma, a challenging cancer of the nervous system.
The Des Moines Register on Friday profiled Planned Parenthood of Greater Iowa, which marks its 75th anniversary this year. Established in 1934 as the Iowa Maternal Health League, PPGI now includes 17 clinics offering a range of reproductive health services, as well as an education and re center. The organization originally was founded by four women with a mission of providing birth control for low-income married women. Over the years, it frequently "has been on the forefront of advances in reproductive history," according to the Register. For example, in the early 1960s, PPGI became the first provider in the Midwest to offer the oral contraceptive Ortho-Novum, leading to a more than 350% increase in its number of patients.Although antiabortion-rights advocates often discuss Planned Parenthood in relation to abortion services, the vast majority of its services are not abortion-related. Jill June, president and CEO of PPGI, said that although the organization"s services have greatly expanded since its founding, the "needs people have for the services we provide and the challenges we face in meeting those needs haven"t changed." She added, "People still face unintended pregnancies despite great technological advances in birth control and efforts to make contraception more available and to normalize contraception use" (Challender, Des Moines Register, 5/22).
Quality of care is not linked to the cost of care, according to a study published last week on the Web site of the journal Health Affairs, CQ HealthBeat reports. For the study, researchers from Dartmouth College and Harvard University analyzed the health care bills of chronically ill Medicare beneficiaries in their last two years of life who received end-of-life care from 2,172 unidentified hospitals. The patients had one of three common conditions: heart attack, pneumonia or congestive heart failure. The study -- sponsored by the National Institute on Aging -- looked at common quality indicators at a hospital-by-hospital level instead of regional level (Norman, CQ HealthBeat, 5/22). Researchers compared the data with some of the quality measures reported on the HHS Hospital Compare Web site (Goldstein, "Health Blog," Wall Street Journal, 5/21). The study found that among the one-fifth of hospitals that spent the least, the cost of end-of-life care was $16,059 on average. In comparison, the cost of end-of-life care at the top 20% of highest-spending hospitals was $34,742 on average. The study also found no link -- or even evidence against a link -- between spending and the quality indicators. The researchers noted that the results might be skewed because the quality indicators they used might penalize hospitals that treat sicker patients. In addition, the study used process-of-care measures instead of patient outcomes. According to CQ HealthBeat, the findings of the study could have an effect on the debate over health care reform legislation because lawmakers and President Obama both have said that a reform plan must be able to control costs and expand access to high-quality, affordable health care (CQ HealthBeat, 5/22).
Over the next 18 months, psychiatrists will revise the American Psychiatric Association"s Diagnostic and Statistical Manual of Mental Disorders, which is used to determine how U.S. residents" mental health is assessed, diagnosed and treated, the Los Angeles Times reports. Since the manual was last updated in 1994, technologies such as brain imaging and new understandings of the biological and genetic causes of many disorders have "almost guaranteed alterations" in the number of mental disorders included in fifth DSM volume, which is scheduled to be published in 2012, the Times reports.While some psychiatrists argue the manual should be broad enough to determine treatment for those who need it, others are concerned that if too broad, the manual will diagnose conditions that would otherwise be considered normal human behavior. David Kupfer, a psychiatrist at the University of Pittsburgh"s Western Psychiatric Institute and Clinics and chair of the DSM-V task force, said the DSM-V will recognize variations of disorders that have not been seen as part of "classic" illnesses, and will describe disorders in more detail, including how they differ based on race, gender, age, physical health and culture. Health insurance companies use the manual to determine coverage options for certain treatments.People involved in the revisions said the manual will be a better reflection of mental conditions of "real" people, rather than just those with the most severe cases of disorders or obvious diagnoses, the Times reports (Roan, Los Angeles Times, 5/26).
Technology Partners, Inc. (dba IMAGINE Software), a leading provider of medical billing technology, recently announced it has attained Gold Certified Partner status in the Microsoft Partner Program with its flagship product IMAGINEradiologyTM, which achieved an ISV/Software Solutions Competency. The company also received a Networking Infrastructure Solutions Competency, recognizing Technology Partners" expertise and impact in the technology marketplace.
In Japan reports of violence linked to SSRI antidepressants have raised
As part of its Centennial Celebration and Conference, Mental Health America-in partnership with the District of Columbia Department of Mental Health-will hold a dedication ceremony on June 10 at 10 a.m. for a memorial planned on the grounds of Saint Elizabeths Hospital for hundreds of thousands of patients who were buried, many with unmarked graves, at state psychiatric hospitals nationwide.
Acculis Limited, the UK based specialist microwave ablation company based in Denmead, England, announced the clearance of its latest device for coagulating and killing unwanted tissue during surgery. The device, designed for coagulations at the surface of the tissue fires controlled high power microwave energy into the target area causing it to heat rapidly and the cells to die. Liver surgeons around the world are using the Acculis MTA System to address tumours inside the liver using its existing needle probes that take the microwave energy to the centre of tumours. Using the same control unit, this latest device allows surgeons to address deposits on the surface of the liver without using a needle. David Lloyd, consultant surgeon from Leicester Royal Infirmary, worked with Professor Nigel Cronin on the device which was also used by consultant HPB surgeons Graeme Poston, Liverpool Aintree and David Sherlock, North Manchester General during the development phase under MHRA control.
New UK research confirms the groundbreaking cancer drug abiraterone provides significant benefit for up to two-thirds of men with advanced and aggressive prostate cancer, according to a study published online in the Journal of Clinical Oncology.
New guidelines designed to standardize and optimize the diagnosis, treatment, and monitoring of patients with Medullary Thyroid Carcinoma (MTC), an uncommon and challenging form of thyroid cancer, have been developed by the American Thyroid Association and published online ahead of print in Thyroid, a peer-reviewed journal published by Mary Ann Liebert, Inc. The guidelines are available free online at http://www.liebertpub.com/thy.
A generation of DNA-like compounds, class R inhibitory oligonucleotides (INH-ODNs), have been shown to effectively inhibit cells responsible for the chronic autoimmune condition lupus. Researchers writing in BioMed Central"s open access journal Arthritis Research & Therapy have demonstrated the anti-inflammatory effects of the INH-ODNs in both in vitro and mouse experiments.
Celleron Therapeutics Ltd, the Oxford UK based specialist in the development of individually targeted cancer medicines, has secured exclusive rights to AstraZeneca plc"s lead histone deacetylase (HDAC) inhibitor (AZD 9468), for global development in conjunction with its proprietary "CancerNav" predictive biomarker platform. "CancerNav" specifically identifies those tumours which are most likely to respond to an individual cancer drug, thereby enabling a highly focussed clinical development and commercialisation programme, based on a closely linked diagnostic and therapeutic "personalised medicine" approach.
Variations in both milk feeding and in the weaning diet are linked to differences in growth and development, and they have independent influences on body composition in early childhood, according to a new study accepted for publication in The Endocrine Society"s Journal of Clinical Endocrinology & Metabolism (JCEM).