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Close Relationship Between Past Warming And Sea-Level Rise
In a paper in Nature Geoscience, a team from the National Oceanography Centre, Southampton (NOCS), along with colleagues from TÃøbingen (Germany) and Bristol presents a novel continuous reconstruction of sea level fluctuations over the last 520 thousand years. Comparison of this record with data on global climate and carbon dioxide (CO2) levels from Antarctic ice cores suggests that even stabilisation at today"s CO2 levels may commit us to sea-level rise over the next couple of millennia, to a level much higher than long-term projections from the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC).

Almirall Announces Filing Sativex(R) - For Treatment Of Spasticity In Multiple Sclerosis - Regulatory Submission
Almirall announces today that the file for a regulatory submission for Sativex® for the treatment of spasticity due to multiple sclerosis has been submitted in UK and Spain under the European decentralised procedure. The UK regulatory authority, the Medicines and Healthcare products Regulatory Agency (MHRA), is acting as Reference Member State and has validated the application.
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U.S. Naval Medical Research Center Proposed 'RESUS' Clinical Trial In Trauma Patients Remains On FDA Hold
Biopure Corporation (Nasdaq: BPUR) announced that the Food and Drug Administration has advised the U.S. Naval Medical Research Center (NMRC) by letter that it may not initiate a clinical trial of Biopure"s oxygen therapeutic Hemopure(R) [hemoglobin glutamer -- 250 (bovine)] under a proposed protocol submitted to the FDA in March 2009. As previously announced, the study, "Restore Effective Survival in Shock" (RESUS) was first proposed and submitted to the FDA in 2005. The proposed trial was placed on clinical hold at that time. It has been resubmitted repeatedly in response to FDA comments and to address comments made by the FDA Blood Products Advisory Committee at an open meeting held in December 2006. Each subsequent submission, including the most recent, was placed on clinical hold.
Sexual Health

Women With Gestational Diabetes During Pregnancy Have A Substantial And Persistently Elevated Risk Of Type 2 Diabetes Post-Birth

Women who develop gestational diabetes (GD) during pregnancy have a seven-and-a-half times increased risk of developing type 2 diabetes post-birth, which lasts throughout their lifetime. However, there is no agreed policy on the long-term follow up of these women and many do not return for the currently recommended 6-week post-birth diabetes check. An Article in this week"s diabetes special issue of The Lancet says that the strength of the association suggests that both disorders have an overlapping cause-and this should act as an incentive for women to attend the recommended post-birth check. This attendance could be an opportunity to provide advice on diet and exercise, and treatments to delay or prevent onset of diabetes-as well as alerting these women to symptoms of future diabetes, and to alert general practitioners responsible for their long-term care. GD is defined as glucose intolerance that is first detected during pregnancy, and affects up to 1 in 20 pregnancies. After birth, the woman"s blood sugar control is restored to pre-pregnancy levels, but affected women remain at high risk of type 2 diabetes in the future. Dr David Williams (Institute for Women"s Health, University College London (UCL) UK) and colleagues from UCL and the London School of Hygiene and Tropical Medicine did a meta-analysis of 20 studies that included some 675,000 women of whom 10,859 developed type 2 diabetes. They found that women with GD were around seven-and-a-half times more likely to develop type 2 diabetes after pregnancy than those with normal blood sugar control during pregnancy. The authors conclude that further studies are needed to establish features for the identification of a mother with GD at particularly high risk of developing type 2 diabetes. They add: "The increased risk in relative risk of type 2 diabetes reported in this meta-analysis might help motivate mothers to attend screening programmes, and health-care professionals to increase uptake to these programmes or perhaps suggest the best time for reassessment. Since the risk of type 2 diabetes seems to be maintained for several years, consideration of whether any form of continuous assessment would lead to health gains is important." "Women who have had gestational diabetes also have increased lipid concentrations and blood pressure, and type 2 diabetes is estimated to confer an equivalent risk of ageing 15 years. Early identification and treatment of these factors could also help to reduce premature cardiovascular and renal diseases in this group of individuals...Resolution of the metabolic changes after pregnancy could provide an opportunity to test the effectiveness of interventions for primary prevention of type 2 diabetes...The effectiveness and cost-effectiveness of interventions would need to be tested in clinical trials." In an accompanying Comment, Dr Rhonda Bentley-Lewis, Brigham and Women"s Hospital, Boston, MA, USA, says: "The present task is to ensure that this information is disseminated to clinicians and that the information is used to target prevention efforts to those who have had gestational diabetes...we as clinicians are afforded the rare opportunity to alter the natural course of disease and change the future health of women today." Link to Article The Lancet


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