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Institute For OneWorld Health And Novartis Launch Innovative Collaboration To Discover And Develop Novel Therapy To Combat Diarrheal Disease
The Institute for OneWorld Health, the US-based non-profit pharmaceutical company that develops drugs for people with neglected infectious diseases in the developing world, today announced that it has launched a collaboration with global pharmaceutical leader Novartis to discover and develop a novel therapy for secretory diarrhea, a deadly disease that kills more than 1.6 million children in the developing world each year.

Latest Erbitux Data On Metastatic Colorectal Cancer Presented At WCGIC Underline Benefits In Patients With KRAS Wild-Type Tumors
Latest Erbitux® (cetuximab) data presented today at the World Congress on Gastrointestinal Cancer (WCGIC) reinforce the value of the targeted therapy in the treatment of metastatic colorectal cancer (mCRC) patients with KRAS wild-type (wt) tumors. Results from the CRYSTALa and CELIMb trials have provided further evidence that KRAS mutation status is the current accepted standard predictive biomarker for Erbitux efficacy in patients with mCRC. In addition, new data have shown that the rash associated with Erbitux therapy can be effectively treated with a cream containing vitamin K.
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Handle With Care: Telomeres Resemble DNA Fragile Sites
Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller University now show that telomeres have their own weakness. They resemble unstable parts of the genome called fragile sites where DNA replication can stall and go awry. But what keeps our fragile telomeres from falling apart is a protein that ensures the smooth progression of DNA replication to the end of a chromosome.
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White House Retools Message As GOP Opposition, Public Opinion Push Back

"[T]he White House team is retooling its message and strategy, hoping a more modest approach will reinvigorate Obama"s signature domestic policy initiative and give him a first-year victory for Democrats to carry into the 2010 midterm elections," the Washington Post reports. An early focus on "fast, broad and bipartisan" reforms has given way to realities including a stiff Republican opposition, lack on consensus in his own party, and falling poll numbers. As a result, the administration and Democratic allies have missed a self-imposed August deadline, turned to harsher critiques of industry players and now appear open to both less-ambitious proposals, and procedural measures that could bypass GOP opposition to achieve a partisan reform bill (Connolly, 8/2). Sen. John McCain, R-Az., Obama"s opponent in the 2008 presidential campaign, suggested that a bipartisan reform may now be out of reach in an appearance on CNN Sunday. "Well, first of all, unfortunately, there was no input by Republicans in the writing of the bill. ò€¦ It was all a Democrat proposal. That"s not the way you want to begin if you"re really interested in a true bipartisan result" (8/2). Meanwhile, the Wall Street Journal reports: "A proposed tax on generous health-insurance packages presents a challenge to President Barack Obama, who promised during his campaign not to raise taxes on the middle class. A plan under debate in Congress would impose a new tax on insurers or employers who provide so-called gold-plated health-care plans. Many economists say a significant part of the cost would eventually be passed to employees, through higher insurance payments or slower wage growth. That could conflict with Mr. Obama"s often-repeated promise not to raise taxes on middle-class families" (McKinnon, 7/31). USA Today reported on administration officials" appearances on the Sunday talk shows: "Treasury Secretary Timothy Geithner and Obama economic aide Lawrence Summers said they could not rule out tax hikes because of the deficit and the potential cost of the health care overhaul. Asked whether "new revenues" are in the offing, Geithner said on ABC"s This Week With George Stephanopoulos: "I think what the country needs to do is understand we"re going to have to do what it takes"" (Jackson, 8/2). In his weekly radio address Saturday, Obama switched "to the economy after several Saturdays of pressing for health care reform," Roll Call reports. Meanwhile, Republicans continued to press the administration on health care. "We need to get the right reform, rather than just rush something through that could leave us in far worse shape in the future," said Sen. John Thune, R-S.D., said in the weekly GOP address (Koffler, 8/1). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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