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Fruitfly Model Of A Neuropathic Disease Demonstrates Novel Role For Proteins In The Family Of ATyr Pharma's Product Class
Research published in the June 26, 2009 edition of Proceedings of National Academy of Sciences provides further evidence for novel roles of tRNA synthetases in disease, validating the therapeutic potential for aTyr Pharma"s new class of naturally occurring protein agents. The aminoacyl tRNA synthetases are universal and essential components of protein synthesis machinery found in all organisms, but human synthetases have naturally occurring resected variants with potent cell signaling activities that are vital to normal functioning of humans. aTyr Pharma"s proprietary product generating engine consists of these resected proteins (resectins) of human aminoacyl tRNA synthetases with cell signaling activities distinct from the protein synthesis activities. In this recently published study, a model of a human neuropathy was created in the fruit fly (Drosophila) by introducing mutations in the tyrosyl-tRNA synthetase which correspond to disease associated mutations in humans. These dominant mutations do not cause a loss in the protein synthesis activity, indicating that the neuropathy arises from distinct activities of this tRNA synthetase. This work provides further proof of noncanonical roles for tRNA synthetases in human disease.
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Local Food Environments Can Lead To Obesity
Living in an area with more fast food outlets and convenience stores than supermarkets and grocers has been associated with obesity in a Canadian study. Researchers writing in the open access journal BMC Public Health have shown that your local food environment can affect your weight.
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Today's Selection Of Opinions And Editorials

HELP Is On The Way New York Times Last week the budget office scored the proposed legislation from the Senate committee on Health, Education, Labor and Pensions (HELP). And the news was good. Yes, we can reform health care (Krugman, 7/6). The Painful Side Effects Of Obama"s Healthcare Reform Los Angeles Times There are warnings signs that the president and his allies are looking at government-run rationing of care for the oldest and sickest (Allen, 7/5). Healthy Intentions Cape Cod Times Without a doubt, it was heartening news when Health and Human Services Secretary Kathleen Sebelius recently acknowledged the deplorable state of health care for many Indians in the U.S. and pledged to do more (7/5). Health Care And How To Pay For It Sacramento Bee As Congress begins to debate in earnest the details of health care reform, the members in Washington would do well to look toward California. The Golden State has the largest number of uninsured in the nation, and our taxpayers bear the burden of providing health care to the biggest population of people on Medicaid, known here as Medi-Cal. We"ve also been pioneers in developing new ways to manage health care and pay for it (7/6). Avoid Rush On Insurance Cures Detroit Free Press There"s much to do, and the Legislature needs to wrap up reforms by year"s end (7/6). Waiting To See The Doc: We Truly Do Apologize Philadelphia Inquirer We are forced to see more patients in less time. Patients expect, rightly so, the best care - but they also expect it to be on time. And that to me, more often than not, is an insurmountable challenge (Rachel K. Sobel, 7/6). Health Care Infectious Losses New York Times With a few small steps, we would no longer have the suffering and death associated with infections acquired in hospitals and we would save tens of billions of dollars every year (O"Neill, 7/6). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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