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Important Therapeutic Target For Breast Cancer: Newly Appreciated Membrane Estrogen Receptor
New research at Rhode Island Hospital has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer. The study is published in the July edition of the journal Molecular Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," says Filardo, "is that it provides some insight into the influence of GPR30 at the cellular level. It shows that estrogen action through GPR30 allows for breast tumor cell survival, and not breast tumor cell proliferation." Prior studies by Filardo"s group showed that estrogen acts through GPR30 to promote the rapid release of preformed growth factors that are tethered to the surface of breast cancer cells. Their latest study was conducted in an effort to better understand the mechanism by which GPR30 triggered the release of epidermal growth factor (EGF) polypeptides from the surface of breast cancer cells.

Questions Over The Gates Foundation's Allocation Of Funds-To Whom Do They Answer?
A paper in this week"s Lancet raises questions about the transparency, accountability and governance of the Gates Foundation (GF). This Health Policy paper is written by Dr David McCoy, Centre for International Development, UCL (University College London), UK, and colleagues. An Editorial and Comment accompany the piece.
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SYNTAX Substudy Shows Positive Outcomes For Left Main Patients Treated With TAXUS(R) Express2(R) Stent System
Boston Scientific Corporation (NYSE: BSX) announced positive outcomes from a substudy of patients with left main coronary disease who were treated with the TAXUS(R) Express2(R) Paclitaxel-Eluting Coronary Stent System. SYNTAX-LE MANS is a substudy of the landmark SYNTAX trial, the first randomized, controlled clinical trial to compare percutaneous coronary intervention (PCI) using the TAXUS Stent to coronary artery bypass graft (CABG) surgery in patients with left main disease and/or significant narrowing of all three coronary arteries (three-vessel disease). The substudy data were presented by A. Pieter Kappetein, M.D., Ph.D., at the annual EuroPCR Scientific Program in Barcelona.
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Swine Flu Pandemic Twist: Humans May Infect Pigs

The strain of influenza, A/H1N1, that is currently pandemic in humans has been shown to be infectious to pigs and to spread rapidly in a trial pig population. In research published in Journal of General Virology, Dr Thomas Vahlenkamp and a team of virologists from the Friedrich-Loeffler-Institut in Greifswald-Insel Riems, Germany, experimentally infected five pigs with the strain of swine flu that is causing the current human pandemic. Within four days the virus had spread to three un-infected pigs housed with the infected ones and all pigs were showing clinical signs of swine flu. "Although in the early stages of the swine flu pandemic there were worries that humans would catch the virus from pigs, this has so far not been documented and pigs and other animals have not been involved in the current spread of A/H1N1 influenza in humans," said Dr Vahlenkamp, "However, with the increasing numbers of human infections, a spill over of this human virus to pigs is becoming more likely. The prevention of human-to-pig transmissions should have a high priority in order to avoid involvement of pigs in the epidemiology of this pandemic". Although the virus spread quickly to the non-infected pigs, it did not spread to five chickens that were housed together with the pigs. This may imply that while the virus can pass from human to pig it does not pass from pig to chicken. The experiments were done under strict containment conditions (Biosafety Level BSL3+), to prevent any further transmission of the virus from the infected pigs. The scientists recommend that persons who are suspected of having swine flu should not be allowed to have contact with pigs and that regulatory bodies should agree on appropriate restriction measures for swine holdings where A/H1N1 infection is detected. Experiments are underway to determine whether currently available vaccines may be able to provide pigs with a certain immunity to stop a potential spread of the virus. Dianne Stilwell Society for General Microbiology


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