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Hebrew U. To Launch Biggest Center In Israel For Brain Research
Israel"s largest institute for brain research will be launched this week at the Hebrew University of Jerusalem. The new $130 million Edmond and Lily Safra Center for Brain Sciences (or ELSC), will be announced in the presence of Mrs. Lily Safra.

2009/039 NICE Guidance Recommends Lenalidomide For Multiple Myeloma
The National Institute for Health and Clinical Excellence (NICE) has published final guidance on the use of lenalidomide for multiple myeloma in people who have received at least one prior therapy.
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Link Between Successful Weight Loss And Vitamin D Levels
Vitamin D levels in the body at the start of a low-calorie diet predict weight loss success, a new study found. The results, which suggest a possible role for vitamin D in weight loss, were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
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Protecting The Heart With Glucocorticoid Drugs

Glucocorticoids are steroid hormones that have numerous functions; for example, they regulate the response to stress and suppress inflammation. Synthetic glucocorticoids are used clinically in many situations, most famously to treat asthma, allergies, and autoimmunity. They have also been shown in animals and humans to help protect the heart from the damaging effects of heart attack, and this has been attributed to their anti-inflammatory effects. However, Motoaki Sano and colleagues, at Keio University School of Medicine, Japan, have now determined another mechanism by which glucocorticoids protect rodent hearts from the damaging effects of heart attack. Specifically, glucocorticoids, acting via the glucocorticoid receptor (GR), induced mouse and rat heart muscle cells to produce PGD2, and this was responsible for the ability of glucocorticoids to reduce damage to mouse hearts in both an ex vivo and an in vivo model of heart attack. The authors therefore suggest that GR-selective glucocorticoids might be more beneficial to humans following heart attack than glucocorticoids that activate both GR and the MR protein, activation of which occurs in response to stress and might have unwanted consequences. TITLE: Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis AUTHOR CONTACT: Motoaki Sano Keio University School of Medicine, Tokyo, Japan. View the PDF of this article at: https://www.the-jci.org/article.php?id=37413 Karen Honey Journal of Clinical Investigation


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