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Celleron Therapeutics And Astrazeneca Announce Personalised Medicine Collaboration In Cancer For The Development Of AZ's Leading HDAC Inhibitor
Celleron Therapeutics Ltd, the Oxford UK based specialist in the development of individually targeted cancer medicines, has secured exclusive rights to AstraZeneca plc"s lead histone deacetylase (HDAC) inhibitor (AZD 9468), for global development in conjunction with its proprietary "CancerNav" predictive biomarker platform. "CancerNav" specifically identifies those tumours which are most likely to respond to an individual cancer drug, thereby enabling a highly focussed clinical development and commercialisation programme, based on a closely linked diagnostic and therapeutic "personalised medicine" approach.

National Health Service Leaflets On Sex Among Teenagers, Elderly Spark Controversy In U.K.
Two leaflets from Britain"s National Health Service have provoked controversy over government messages on sexuality among teenagers and the elderly, the Washington Post reports. According to the Post, the leaflet for teens, titled "Pleasure," says that daily sex "keeps the doctor away." It also states, "Health promotion experts advocate five portions of fruit and [vegetables] a day and 30 minutes physical activity three times a week." It suggests that some form of sexual activity "twice a week" could have health benefits as well. The leaflet was issued by NHS in Sheffield, England, and is available to parents, youth workers and teachers nationwide. The leaflet for the elderly says that it is "never too late to experiment" sexually and offers information on dating services and contraception. The leaflet is available online, and 2,000 copies have been distributed to doctors" offices, health centers and libraries.Britain has the highest teen pregnancy rate in Western Europe, and the government has prioritized prevention-related policy measures by spending millions of dollars on awareness and contraception campaigns, the Post reports. The country also plans to make sex education mandatory in all public schools starting in 2010.After the teen leaflet appeared, "dismayed parents lit up message boards," and some educators argued that it "encouraged promiscuity," the Post reports. However, others said the leaflets are a welcome departure from traditional forms of sex education that focus on biology and disease prevention, rather than personal relationships. Hilary Pannack, CEO of the teen pregnancy not-for-profit Straight Talking, said that talking with teens about sexual pleasure "should be done with extreme caution" but that, in general, the leaflet is a "big turnaround for Britain." She added, "British people are very, very embarrassed talking to kids about sex."Steve Slack, the director of NHS" Center for HIV and Sexual Health in Sheffield and a co-author of the leaflet, said one of the objectives was to encourage teens to delay intercourse until they are ready and feel that they will enjoy it. He added that some of the leaflet"s ideas were inspired by the Netherlands, a country that is frequently referenced in British sex education debates because of its liberal attitudes toward discussing sex and its low teen pregnancy rates (Adam, Washington Post, 7/23).
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BioCryst Pharmaceuticals Announces Presentation Of Forodesine Data At The 45th Annual Meeting Of The American Society Of Clinical Oncology
BioCryst Pharmaceuticals (Nasdaq: BCRX) announced long-term data from a Phase 2 study of forodesine, the Company"s lead oncology compound, in patients with cutaneous T-cell lymphoma (CTCL). The data will be presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO) being held in Orlando, Florida from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.
Medical Devices

More Women Seek Nonprescription Remedies For Menopause Symptoms

Over-the-counter remedies for menopause symptoms are growing in popularity among some women who fear potential risks from prescription hormone replacement therapy, the New York Times reports. According to the Times, the market for alternative therapies -- such as natural supplements and topical creams -- jumped in 2002 after initial results from the Women"s Health Initiative suggested that HRT could increase risk for heart disease, cancer, stroke and blood clots. Gynecologists estimate that about one-third of menopausal women are treated with conventional prescription hormones, and about one-third are treated with bio-identical hormones -- plant-derived synthetic hormones that mimic the molecular structure of human hormones. The remaining one-third either do not seek therapy for symptoms, are not bothered by symptoms or use over-the-counter therapies. There are more than 500 over-the-counter products available that claim to alleviate menopause symptoms, the Times reports. The treatments include such products as teas, low-dose progesterone creams, black cohosh capsules and phytoestrogens derived from soy and red clover, according to the Times. According to Nutrition Business Journal, the U.S. dietary supplement market associated with menopause increased from $211 million in 1999 to $337 million in 2007.Some studies have raised doubts about the safety and effectiveness of the over-the-counter remedies. Todd Cooperman -- director of consumerLab.com, a private nutrition product-testing lab -- said that his company"s study of more than one dozen products found that five failed to gain the lab"s approval because of problems such as inaccurate labeling or tainted ingredients. The Center for Botanical Dietary Supplements Research this fall is expected to release the results of a study, sponsored by the National Institutes of Health, that aims to determine the efficacy of the ingredients associated with menopause symptom relief. Some studies have questioned the efficacy of progesterone creams, which some experts contend can gather in fat cells and disrupt the production and synthesis of other hormones. Other experts maintain that the products are safe if properly used. Theresa Ramsey, director of the Center for Natural Healing in Arizona, said, "I think over all these products are generally safe, but must be taken in the right circumstances and in conjunction with a mindfully healthy approach to life if they are going to be effective at all" (Sweeney, New York Times, 7/2). Reprinted with kind permission from http://www.nationalpartnership.org. You can view the entire Daily Women"s Health Policy Report, search the archives, or sign up for email delivery here. The Daily Women"s Health Policy Report is a free service of the National Partnership for Women & Families, published by The Advisory Board Company. © 2009 The Advisory Board Company. All rights reserved.


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