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Affymax Reports Phase 2 Clinical Trial Data Supporting Hemoglobin Increases With Once-Per-Month Hematide Regardless Of Patient Baseline Renal Function
Affymax, Inc. (Nasdaq:AFFY) today announced data from a post hoc analysis of 120 patients in a Phase 2 clinical trial of Hematide™ in non-dialysis chronic kidney disease (CKD) patients. The data suggest that there is no major impact of baseline renal function as measured by Estimated Glomerular Filtration Rate (eGFR) on the monthly Hematide dose required to increase and maintain hemoglobin (Hgb) values within target range in non-dialysis CKD patients. The data were presented by Iain C. Macdougall, M.D. at the World Congress of Nephrology meeting being held in Milan, Italy.

Finding The Best Heart Disease And Stroke Treatments For Patients With Diabetes Using New Tool
Researchers from North Carolina State University and Mayo Clinic have developed a computer model that medical doctors can use to determine the best time to begin using statin therapy in diabetes patients to help prevent heart disease and stroke.
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Generation Of A Severe Memory-Deficit Mutant Mouse By Exclusively Eliminating The Kinase Activity Of CaMKIIalpha
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dependent synaptic plasticity and memory functions. However, the causative role of the enzymatic activity of CaMKII alpha in such processes has not been demonstrated yet, because this enzyme has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr Yoko Yamagata of the National Institute for Physiological Sciences, Japan, has successfully generated a novel kinase-dead mutant mouse of the CaMKII alpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in the Journal of Neuroscience, published on June 10, 2009.
Medical Devices

Companies Warned To Follow Correct Safety Procedures When Operating Machinery And Drills, UK

The Health and Safety Executive (HSE) is warning employers and their staff to be mindful of following the correct safety procedures when operating machinery and drills, following the prosecution of a West Bromwich firm. An employee at Aluminium Products Ltd lost part of his index finger during an incident on 15 October last year. The company was fined ÷£4,000 and ordered to pay ÷£2,423 costs in the West Bromwich Magistrates" Court on 15 June, yet the incident could have been prevented by a ÷£60 safety guard. The company, which is based in Haines Street, West Bromwich, pleaded guilty to breaching Section 2 of the Health and Safety at Work Act 1974. The court heard how the employee was working with a pedestal drill, when his hand slipped from the block. His glove was caught in the rotating drill, amputating part of his index finger. A risk assessment had identified drill guarding and the provision of jigs as necessary safety controls, but neither safety measure had been used. Prosecuting, HSE inspector Lee Perry said: "This worker has suffered a life-changing injury in an incident that was preventable. This was an unsafe system of working, and the speed and economy with which remedial measures were put in place after the accident - a telescopic guard was installed within a couple of days at a cost of just ÷£60 - shows this accident could have been avoided. "HSE publishes Approved Codes of Practice, guidance and information leaflets with practical advice on machinery guarding - so there is no excuse for duty holders who don"t control risks and protect their employees." Notes 1. Section 2 of the Health and Safety at Work etc 1974 states: "It shall be the duty of every employer to ensure, so far as is reasonably practicable, the health, safety and welfare at work of all his employees." HSE


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