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Depression May Cause Patients To Become Less Active
Feelings of depression could be one reason patients fail to follow their doctors" orders on exercising and eventually become less physically active, a new research review finds.

What Is Post Traumatic Stress Disorder? What Is PTSD? What Causes PTSD?
PTSD (Post-Traumatic Stress Disorder) is triggered by a traumatic event - it is a kind of anxiety. The sufferer of PTSD may have experienced or seen an event that caused extreme fear, shock and/or a feeling of helplessness. Most of us experience a brief period of difficulty adjusting and coping with traumatic events. However, we gradually get better with time and healthy coping methods. On the other hand, there are times when symptoms get worse and may last for several months, or years. This study explains how PTSD can surface two years after a traumatic event. Another study found that one in eight Lower Manhattan residents likely had PTSD two to three years after the 9/11 attacks.
News of the day
Vaginal Infections 'symptom Sorter' Launches To Help Women Get Diagnosed And Treated
Three quarters (75%) of women with BV (Bacterial Vaginosis) admit the condition has prevented them from getting intimate with their partner, according to a new survey by Balance ActivTM Vaginal Gel.1 Sufferers reveal BV affects their personal relationships more than any other aspect of their lives, with one in ten sufferers resorting to ending relationships as a result of the embarrassing symptoms.1
Sexual Health

Almirall Announces Filing Sativex(R) - For Treatment Of Spasticity In Multiple Sclerosis - Regulatory Submission

Almirall announces today that the file for a regulatory submission for Sativex® for the treatment of spasticity due to multiple sclerosis has been submitted in UK and Spain under the European decentralised procedure. The UK regulatory authority, the Medicines and Healthcare products Regulatory Agency (MHRA), is acting as Reference Member State and has validated the application. This submission follows the recent announcement of positive results in a Phase III study where Sativex® showed relevant improvement of the spasticity"s evolution in multiple sclerosis patients. It is expected that an outcome of the regulatory submission will be known around the end of 2009 or early 2010. Following approval in the UK and Spain, submissions for approval would be made in other European countries during 2010 under the mutual recognition procedure. Almirall has the marketing rights of Sativex® all over Europe, except the UK. Treatment of spasticity due to multiple sclerosis is expected to be the first indication which is presently undergoing other Phase IIb clinical trials for the treatment of cancer pain. "Sativex® will be the first new treatment for the symptomatic relief of spasticity in 10 years and these are encouraging news for patients suffering of spasticity due to multiple sclerosis," comments Luciano Conde, Chief Operating Officer at Almirall. "Sativex® will represent an interesting add-on to Almirall"s pipeline in the central nervous system arena" he added. About Sativex® Sativex®, researched and developed by GW Pharmaceuticals (UK), is a plant-based medicine and its formulation is basically a combination of two cannabinoids: tetrahydrocannabinol (THC) and cannabidiol (CBD). This unique formulation brings out the therapeutic benefits of the cannabinoids while at the same time minimizing adverse and unwanted effects such as intoxication, sedation or psychotropic effects. Sativex® is administered through an oralmucosal spray. The formulation allows a flexible dosage depending on each patient -at all times following medical instruction-, making it particularly appropriate due to the variable nature of spasticity and multiple sclerosis (MS). Sativex® is approved and marketed in Canada for the treatment of cancer pain and MS neuropathic pain. In addition, this medicine is available on prescription in the UK on a "named patient" basis and has to date been exported to 21 countries around the world. Spasticity, a serious symptom of MS Spasticity (muscular spasms and stiffness) is one of the most common symptoms of MS occurring in approximately 75% of patients. Spasticity can affect many aspects of daily life, such as walking and sitting. Sativex® aims to treat high need patients who have previously failed to gain adequate benefit from currently available anti-spasticity treatments. Results of a Phase III Trial on spasticity in MS On 11th March 2009, GW announced positive preliminary results from a pivotal Phase III double-blind randomised placebo-controlled study of Sativex® in patients with spasticity due to Multiple Sclerosis (MS), who have achieved inadequate spasticity relief with existing therapies. This study was requested by the UK regulator in order to gain approval in this indication. The prospectively defined primary efficacy endpoint of the study -the difference between the mean change in spasticity severity with Sativex vs Placebo- was highly statistically significantly in favour of Sativex (p=0.0002). The difference between Sativex and placebo was also highly significant for a number of secondary endpoints, including the 30% responder analysis (p=0.0003), spasm frequency (p=0.005), sleep disturbance (p Almirall


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