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British Medical Association Cymru Wales Launches The 'Option 7' Campaign - To Improve The Lives Of Junior Doctors
BMA Cymru Wales on Monday launched a campaign aimed at improving the working lives of junior doctors in Wales.

Policymakers, Experts, Public Agree: Physical Activity Plan Needed
Dozens of the nation"s leading organizations in health care, science, medicine and public health are meeting in Washington, D.C., this week with one goal in mind: to develop a national physical activity plan that will make America healthier. Congressional leaders and members of the public both agree that emphasizing disease prevention measures, such as increasing physical activity, is essential to combating chronic diseases, which account for 70 percent of all deaths in the U.S., according to the Centers for Disease Control and Prevention.
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Response To Carotid Endarterectomy Audit
Joe Korner, Director of Communications at The Stroke Association said: "This audit shows that there is still a long way to go to make sure people get urgent preventative treatment that could prevent a catastrophic stroke.
Medical Devices

A Link Between The Circadian Rhythm And Salt Balance

New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice. The hormone aldosterone regulates levels of sodium in the blood and thereby helps control blood pressure. Although it is known that aldosterone regulates sodium levels by controlling expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney, the molecular pathway by which aldosterone modulates alpha-ENaC levels has not been determined. In a previous study to address this issue, Wingo and colleagues found that aldosterone induced expression of the circadian clock gene Per1 in mouse cells, but the effects of this induction were not investigated. In this new study, they have revealed that the protein produced from the Per1 gene (Period 1) regulates expression of alpha-ENaC in the mouse kidney. Importantly, in the absence of Period 1, expression of alpha-ENaC in the mouse kidney was decreased and sodium loss in the urine was increased. Since expression from the Per1 gene seemed to follow a circadian pattern, the authors suggest that the circadian clock has a role in balancing sodium levels in the body. TITLE: The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice Karen Honey Journal of Clinical Investigation


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